Posts Tagged ‘stem cells and multiple sclerosis’

Kay’s New Lease On Life Following Stem Cell Treatment

Tuesday, March 18th, 2014

Kay Jarrett MS

Eight years after doctors told her she had multiple sclerosis, Kay Jarrett is going to the gym regularly, taking walks and doing things that had been impossible for a couple of decades.

“I haven’t felt this good in years,” she said enthusiastically.

“It’s like I’ve had new batteries put in.”

The difference has come about through a revolutionary form of stem cell therapy undertaken at a clinic in Queensland.

Kay’s story has strong parallels to one aired last week on television show Sixty Minutes, detailing how a young mother had to travel to Russia for stem cell treatment to stop her continued decline caused by multiple sclerosis.

While treatment meant the woman on television was able to start jogging after a previously being confined to a wheelchair, Kay said the differences in her life might have been less dramatic but they were equally important to her.

“I have a whole new lease on life now,” Kay said.

That difference was illustrated in the days following the Milton Show.  Kay works in the show’s horse ring each year and said the effort exhausted her so much she normally spent a week in bed after the show.

However this year she was up and about the next day, able to continue with her life without the need for recovery time.

“It’s wonderful, I feel like a new person,” she said.

Kay’s transformation came through a seven-hour procedure in a Queensland medical clinic, which started with fat tissue being removed from her abdomen.

Fat tissue is rich with adult stem cells, which can differentiate into a range of different cells around the body.

The stem cells were then separated from the remainder of the fatty tissue, before the stem cells were mixed into a solution fed back into Kay’s blood system though an intravenous drip, along with medication to aid the cells being absorbed into her system and repair damage caused by the multiple sclerosis.

Once the swelling died down Kay was up and about, enjoying the things that had been difficult for many years.

Even walking has provided a new-found pleasure, as regular leg spasms and a tendency to stumble and fall, previously combined with the fatigue so often associated with MS, making it difficult to get about.

She has even managed to reduce the amount of medication she takes each day, and her memory has improved.

While she previous spent much of her life isolated from the rest of the world, Kay has plans to “get back out there”.

“I want to live life to the fullest now I feel better,” she said.

She is also determined to continue fundraising to help others cover the cost of stem cell treatments, as costs could top $12,000.

“I want to help others have stem cell treatment and feel as good as I do,” she explained.

“I know a few people in the local area who desperately need it, but I need the town to get behind me to support the fundraising.”

Source:    By Glenn Ellard – Milton Ulladulla Times, Australia

 

Scientific Support for Treatment for Multiple Sclerosis

Monday, May 21st, 2012

A Study conducted by Case Western Reserve University Scientists finds improvement with Mesenchymal Stem Cell Signals in Animal Models of Multiple Sclerosis. Mesenchymal stem cells (MSCs) are adult stem cells traditionally found in the bone marrow.

The Myelin Repair Foundation (MRF) today announced the results of a new peer-reviewed research study published in Nature Neuroscience that demonstrates functional improvement in immune response modulation and myelin repair with factors derived from mesenchymal stem cell (MSC) treatment in animal models of multiple sclerosis (MS). Funded by the Myelin Repair Foundation, this research conducted by Case Western Reserve University scientists showed positive results with human mesenchymal stem cells in animal models of MS by not only successfully blocking the autoimmune MS response, but also repairing myelin, demonstrating an innovative potential myelin repair treatment for MS.

Multiple sclerosis is a disease of the immune system that attacks the myelin, causing exposed nerves or “lesions” which block brain signals, causing loss of motor skills, coordination and cognitive ability. Compared to the controls, this research study showed fewer and smaller lesions found on the nerves in the MSC treatment group. MSCs were found to block the formation of scar tissue by suppressing the autoimmune response, which would otherwise cause permanent damage to the nerves. Furthermore, the research showed that MSC treatment also repaired myelin, enhancing myelin regeneration of the damaged axon and the rewrapping of the myelin around the axon in animal models of MS. One treatment of MSCs provided long-term protection of the recurring disease.

Led by Myelin Repair Foundation Principal Investigator and Vice President for Research & Technology Management at Case Western Reserve University’s Dr. Robert Miller, this study documents a new promising pathway for treating multiple sclerosis that blocks the autoimmune response and reverses the myelin damage in animal models of MS. The human MSCs used in this study were culled from adult stem cells derived from the bone marrow.

“We are thrilled with the publication of this important research study that examines a new pathway to treat multiple sclerosis, one that reverses the damage of the disease,” said Dr. Robert Miller. “Since we were just beginning to understand how MSCs provide myelin repair for lesions, with the Myelin Repair Foundation’s support, we continue to deepen our knowledge of exploring the next generation of MS treatments that stimulate healing, rather than symptom suppression of the disease.”

“We pride ourselves on supporting best-in-class scientists devoted to find new ways to treat multiple sclerosis, advancing highly innovative research projects that otherwise would not have moved forward,” said Scott Johnson, president of the Myelin Repair Foundation. “The success of Case Western Reserve University’s study and recognition in this prestigious journal furthers our goal to identify new pathways to treat multiple sclerosis by supporting a multi-disciplinary team of the best researchers in the field.”

About the Myelin Repair Foundation

The Myelin Repair Foundation (MRF) ( http://www.myelinrepair.org ) is a Silicon Valley-based, non-profit research organization focused on accelerating the discovery and development of myelin repair therapeutics for multiple sclerosis. Its Accelerated Research Collaboration(TM) (ARC(TM)) model is designed to optimize the entire process of medical research, drug development and the delivery of patient treatments.

SOURCE: Myelin Repair Foundation