Posts Tagged ‘healthcare advancements’

Health and Technology Advancements

Monday, July 5th, 2021

Despite the great strides that modern technology has given us, there are still incredible discoveries that humanity has not yet made. Among them is the solution to live a lot longer in a very healthy body. This article looks at five of these advancements.

1.      Genetic Anti-Aging Tools

Several approaches to gene editing are being developed by scientists around the world. These technologies allow genetic material to be added, removed or altered in particular locations in the genome to replace worn out DNA.

One of the latest developments involves injecting a special gene into the human body in the hope that it completely changes the rules by which the human body operates.   This approach looks at extending the maximum number of cell divisions and ensuring a longer life.

There are two distinct ways gene editing can be used in humans. Gene therapy, or somatic gene editing, changes the DNA in cells of a human to treat disease or provide enhancement in some way. The changes made in these somatic (or body) cells would be permanent for the person being treated. One way this is already being done is by editing a person’s immune cells to help them better fight cancer. Clinical trials using CRISPR (clustered regularly interspaced palindromic repeats) whereby blood cells are edited have proved very successful in recent clinical trials, particularly for those with blood disorders.

The second, and much more controversial way that human gene editing could be used is germline modification.  This involves changing the DNA of embryos, eggs, or sperm. Because germline DNA is passed down to all future generations, any changes (whether they be beneficial or harmful) would be as well. Some have proposed that germline editing could be used to prevent inherited diseases. Human germline editing has not only scientific or technical issues, it has many implications for society as a whole, not just individuals. Decisions about whether to permit germline modification need to be taken very seriously.  

2.     Stem Cell Therapy

Stem cell treatments are showing a great deal of promise in terms of injury repair and renewal, disease cures and control.  Almost all stem cell clinical trials and therapy utilize and/or use adult stem cells (these are stem cells that reside in our own bodies after we are born) and they do not have the controversy that is associated with embryonic stem cells.  The global stem cell market is projected to grow at 8.8% from 2021 to 2028 to reach USD 18.41 billion by 2028. Regenerative medicine holds the largest market share of growth at 89.1%.  This growth is due to the ever-increasing approval of stem cell clinical trials targeting many different diseases. 

Scientists worldwide acknowledge that stem cell treatment can significantly enhance the performance and repair of the human body.  This is why so many athletes turn to stem cell therapy as it is non-evasive and provides a very quick recovery period compared to surgery.

Cell activation and cultivation does not allow you to live forever, but it significantly slows down aging. Active, healthy stem cells (defined as “adult stem cells” that reside in your bone marrow, blood, tissue, muscle, and organs) have amazing qualities. Adult stem cells are capable of providing strong immunity, as well as reconstructing and repairing membrane structures. By activating and replacing old or dying cells, it is possible to maintain human health for a much longer period of time. 

Stem Cell Worx is the world’s only patent approved stem cell supplement in an intraoral spray.  Its immediate absorption rate of 95% enables the pure, natural nutrients to get directly into the bloodstream to activate one’s own stem cells. This liquid spray rapidly provides the onset of benefits that include building the immune system, rapid repair and renewal, more energy and less inflammation.   

3.     3D Printing

3D printers are now used in a number of Hospitals to ensure moldings are exact to provide a customized fit for the patient. Not only are they used to construct customized prosthetics for patients, they also print other medical items including surgical scaffolds, tools, tissues and organoids. 

3D printers are also getting closer to being able to produce organs. In 2018, researchers at the University of Utah became the first to produce ligaments and tendons by extracting stem cells from a patient’s body fat, printing them in 3D onto a layer of hydrogel, allowing time for the cells to form the required connective tissue outside the body and then implanting where needed.  This important breakthrough led the way for more recent advancements as injuries to tendons and ligaments had in the past proven to be difficult to treat.

Dental professionals have been one of the first professions to use scanning and printing technology to create customized dental implants, prosthetics and braces.  This equates to a much more efficient and timely in-house service. There are no bounds to what 3D printers will bring to healthcare in the near future. 

4.     Cryo-freezing

Cryonics is the process of freezing until the time comes when scientists find the secret of resurrection.

The most well-known and longest operating cryonics facility, Alcor is in Scottsdale, AZ, U.S.A.  A number of patients and pets are housed at this facility. The dead person is frozen to stop tissue necrosis and this leaves the brain cells unchanged. Like anything frozen, frostbite or damage is a real risk.  Alcor’s website says it has improved its technology and discovered breakthroughs in organ banking that will reduce damage or injury from the freezing process. Meanwhile, cryonics research and technology development is growing with other storage facilities in Michigan, Miami, Oregon, and countries China and Russia.

Reviving whole bodies has challenges as organs need to commence function homogeneously and there needs to be no cell damage.  Another huge hurdle for cryonics is to not only repair the damage incurred due to the freezing process but also to reverse the damage that led to death and in such a manner that the individual resumes conscious existence.  This procedure also requires a lot of funds and resources.  A cryo capsule is needed to store the patient and this takes space and needs constant control.  A successful cryosleep is yet to be attempted but scientists in this field are confident it will be attempted in the next 20 years.

5.     Reconstruction of Consciousness

When a body becomes unsuitable for life, there is a hope that with the help of neuroscience, scientists will be able to transmigrate human consciousness into a new shell. At this stage, there are three options for a potential shell that are being explored.

The first option is where consciousness can potentially be transferred to another human body. The new body is a ready and working shell. But two people cannot exist in one body, which means that the old host must be destroyed or a new body must be grown artificially.

The second option is cloning an organism for further use as a backup shell in case something happens to the main one. Such technologies are very difficult and resource intensive.  Cloning experiments are very hard to get off the ground as this practice is widely considered unethical on many levels.  

The third option is to create a cyborg. This is one of the most breakthrough approaches to date. Already, thousands of people use robotic limbs in their lives. The creation of implants is not as expensive as the previous two. Human modifications can become more effective than the originals and can greatly improve human life with strict regulations in place.

Watch this space as these developments progress.

Healthcare – What’s On The Horizon In 2016

Monday, January 11th, 2016

Healthcare Breakthroughs

A new paradigm is emerging in the world of healthcare.

These are very exciting times for the healthcare and life science sectors as clinical trials and research demonstrate understanding of aging and disease at the cellular and genetic level. This understanding is enabling new therapies and treatments to be backed and then developed like never before.

Biomedical advancements are at the forefront of this paradigm and they are set to transform global health.  These developments are enabling early diagnosis and therapeutic intervention for chronic and killer diseases including autoimmune diseases, blood disorders and cancer.

The top six scientific and healthcare developments to be tracked in 2016 are:

1.   Immuno-oncology 

It is one of the most promising fields of science being explored by scientists to help develop customized solutions. Some spectacular advancements were made in this area in 2015, with a market opportunity of $40 billion forecast by 2025, (source: Leerink Partners).

PD-1 (programmed death-1) and PDL-1 (programmed death ligand-1) targeting antibodies and Chimeric antigen receptor T-cells (CART), have demonstrated how treatments and technology can be leveraged for developing ground-breaking therapies in immuno-oncology. The US Food and Drug Administration (USFDA) recently approved a drug that relies on a genetically-engineered version of the herpes virus to kill cancer cells and stimulate immune response against malignant tumors in skin cancer patients. Several other immune-stimulating viral therapies are also being evaluated with the hope that they can be developed further. One example is a genetically-modified polio virus to fight brain cancer and the re-engineering of the common cold virus in the hope that it will treat a form of bladder cancer.

2.   Stem Cell Therapy 

Stem cell therapy is providing new hope in not only curing a number of debilitating diseases but also building  organs in the Laboratory.   A number of scaffolds have already been built and engineered and successfully trialed in patients.

Scientists believe stem cell therapy is key to managing cancer, heart diseases, diabetes, Parkinson’s disease and many more diseases in the near future.  Over 150 diseases are being stabilized and in some cases cured using stem cell therapies.

Healthy stem cells have the remarkable potential to develop into many different cell types within the body throughout one’s entire lifetime. They serve as an internal repair system, dividing to replenish and rejuvenate other cells as long as the person or animal is alive.

Just recently the Therapeutic Goods Administration (TGA) in Australia gave its first go-ahead to human studies for a revolutionary stem cell therapy aimed at halting/reversing the progression of Parkinson’s disease, which affects up to 10 million people worldwide.

Scientists in Australia have also achieved a medical breakthrough to enable stem cells to form different cell types found in the kidney.  Initially it was thought only stem cells could rejuvenate the type of cells they were sourced from. However, more recent science (in the last decade) shows that in the right environment and with the help of specialized activators and proteins, stem cells have far greater repair and renewal capabilities throughout the entire body.

3.   3D Printing

A Bengaluru-based tissue engineering start-up has made India’s first artificial human liver tissue with the help of 3D printing technology, using 10 million liver cells. This is a milestone that showcases the tremendous potential of 3D printing technology in organ development. It has the potential to save many lives.

3D printing is already changing lives.  People who have had countless hip replacements because the standard mold doesn’t fit are now benefiting from 3D printing molds that fit their joint perfectly, putting an end to endless correction surgeries.

4.   Biomarkers and Companion Diagnostics

Today, biomarkers are providing a wealth of biological data.  These biomarkers are predicting drug failures before expensive clinical trials are carried out. They are also allowing scientists to identify patient pools a lot sooner in terms of who is likely to respond favorably to a particular drug.

We already have cancer drugs for patients with specific genetic mutations. This has led to the emergence of companion diagnostics, which screens patients for biomarkers that gauge the safety and efficacy of a particular treatment. Recently, the USFDA approved the first companion diagnostic to detect a protein associated with lung cancer while approving Merck’s Keytruda drug for the disease. The companion diagnostic will enable doctors to determine whether patients have high enough levels of the PD-L1 biomarker for Keytruda in order for it be effective. Now, more sophisticated companion diagnostics are being developed to assess patients for multiple biomarkers related to multiple drugs.

5.   Genomic Sequencing

Genomics has created a new breed of life scientists and researchers, who look at disease in a very different way.  A number of initiatives are underway including the US-based medical geneticist Robert Green’s MedSeq Project which looks at ways in which the profusion of genomics data and other clinical information can be integrated with day-to-day medical practice in order to assist the medical fraternity in determining a specific line of treatment for their patients.

Already, genomic sequencing is being combined with molecular diagnostics, imaging and data analytics to decipher the cellular structure of malignant tumors and develop treatment regimens.

Billionaire Dr. Patrick Soon-Shiong of Los Angeles is turning heads with his unconventional ways of treating cancer. Dr Soon-Shiong has appointed himself to lead his genome revolution. Cancer genome sequencing is not new but what’s different about Soon-Shiong’s project is the scale. He has spent nearly a billion dollars of his own money to build a massive infrastructure, run by super computers, to find every single genetic mutation that could drive cancer.

This is Soon-Shiong’s plan in the future: A patient, anywhere in the world, has his tumor biopsied. The tumor cell’s complete genetic map is then created all the way down to the proteins that are produced. What recently took months can now be done in a day. Soon-Shiong’s ultimate plan is for personalized information for each cancer patient to show up in the palm of his hand ready for the appropriate treatment to be applied, and this concept is not that far off.

6.   Biosimilars 

The development of biosimilars will provide affordable access to complex biologics in 2016. The first-ever USFDA approval for a biosimilar was granted to Filgrastim in 2015. Encouraging developments in highly regulated markets point to the evolution of abbreviated clinical pathways that will allow speedier entry of biosimilars. With $48 billion worth of patents on a number of blockbuster biologics set to expire soon, the global biosimilars market is poised for rapid growth.

India is well poised to play a significant role in the biosimilars area where companies like Biocon, Dr Reddy’s, Intas, Zydus Cadila and others are engaged in developing high quality biosimilars to provide affordable access to these complex biologics.

Indian patients have had access to some of the biosimilars like Insulins, Analogs, Filgrastim etc. since early 2000s and more recently complex antibodies like Trastuzumab, Rituximab, Adalimumab etc have also been introduced. This early experience with developing biosimilars will pave the way for Indian players to capitalize on this unfolding global opportunity.

Extraordinary Times

We are living in extraordinary times.  Science and technology combined is revolutionizing the way healthcare is being provided. Cancer is no longer a death sentence but a manageable chronic disease. We are witnessing the development of innovative therapies like no time in history before.

Clearly, it is time to look out for this new paradigm in global healthcare where the blind will see, the deaf will hear and the paralyzed will walk.