Posts Tagged ‘top supplement’

2012 Olympic Games – Athletes Use Bovine Colostrum

Tuesday, March 27th, 2012

Scientists investigating natural ways to enhance athletic performance have found that bovine colostrum can massively reduce gut permeability – otherwise known as ‘leaky gut syndrome.’  Their findings, published in the March issue of the American Journal of Physiology-Gastrointestinal and Liver Physiology, could have positive implications not just for athletes but also for sufferers of heatstroke.

A research group led by Ray Playford, Professor of Medicine at Barts and The London School of Medicine and Dentistry looked at athletes who were asked to run for 20 minutes at 80 per cent of their aerobic maximum. At the end of the exercise, changes in the subjects gut leakiness were measured using urine sample – also determined were changes in the athletes’ core temperature.  Under standard conditions, gut leakiness had increased by 250 per cent and temperature had risen by 2 degrees.  However, when the group were given a drink of dairy colostrum for two weeks before the trial, the rise in gut leakiness was reduced by about 80 per cent, despite the same effort and temperature rise.

Gut disorders induced by exercise are common in runners – the body’s response to increased permeability is to clear the gut contents, giving rise to symptoms such as diarrhoea to avoid toxins from gut organisms entering the bloodstream, as these lead to heatstroke which can result in damage to the internal organs.

Professor Playford’s research identified changes in gut barrier function in laboratory studies: gut cells were cultured at normal 37 degrees body heat and at 39 degrees to replicate the temperature after exercise. The death rate of gut cells was much increased at the higher temperature yet when colostrum was added to the culture medium the rise in cell death rate was reduced by two thirds.

Professor Ray Playford said: “Athletes’ performance can be seriously diminished due to gut symptoms during heavy exercise. We have been looking at natural approaches to reduce this problem as the range of products that athletes can legitimately take is very limited. Our findings suggest colostrum may have real value in helping our athletes perform. This is a research area we are especially interested in given our proximity to the 2012 Olympic site. In addition, extremes of temperature and exercise are often suffered by armed forces in desert war scenarios and can result in heat stroke which is life threatening. Based on our results to date, our research group is also exploring products that may be useful for protecting soldiers in life threatening situations such as these.”

More information: on the benefits of  bovine colostrum and how it assists athletes is published in the March issue of American Journal of Physiology-Gastrointestinal and Liver Physiology (http://ajpgi.physiology.org/)

Stem Cell Trachea Transplant

Saturday, January 14th, 2012
As reported on ABC by LARA SALAHI

Christopher Lyles is the first U.S. patient to undergo a tracheal transplant using his own stem cells.

Christopher Lyles, 30, of Abingdon, Md, exhausted the limited treatment options available in the U.S. for his tracheal cancer. But Lyles read about an experimental tracheal transplant procedure surgeons performed in Europe using adult stem cells.

“Every surgeon told me it was inoperable,” said Lyles. “It was hard to hear that.”

Lyles reached out to Dr. Paolo Macchiarini, director of the Advanced Center for Translational Regenerative Medicine at the Karolinska Institute in Stockholm, who was the head surgeon in previous transplant cases.

After a 12 hour procedure in Sweden, Lyles was breathing through a lab grown windpipe that doctors fashioned from his own stem cells.

Doctors regenerated tissue from Lyles bone marrow stem cells to create a trachea biologically identical to Lyles original organ. Lyle underwent the transplant in November and arrived back home Wednesday.

Within three months, Lyles was able to eat and speak on his own, he said.

“I’m going one step further every day,” said Lyle.

According to Dr. Mark Iannettoni, Head of the Department of Cardiothoracic Surgery at University of Iowa, a trachea is a fragile organ because it is mostly cartilage, which has a poor blood supply.

“Once damaged, it is difficult to get it to heal correctly,” said Iannettoni.

In June 2011, Lyles was diagnosed with a rare form of trachea cancer. Unlike some patients with the same condition, Lyles’ tumor extended below his thyroid gland and did not affect his voice box.

Trachea cancer is resistant to chemotherapy and radiation and attempts to replace the trachea with mechanical devices have not been effective.

Lyles’ first underwent seven rounds of chemotherapy and 33 rounds of radiation treatment between July and September.

Using a patient’s own stem cells not only could help to rebuild the fragile tissue, but also potentially could bypass the risk of having the organ rejected, according to Dr. Eric Lambright, surgical director of lung transplant at Vanderbilt University Medical Center, who was not involved with the procedure.

“These patients [are] otherwise sentenced to rather significant horrible quality of life related to their tumors and heroic measures may indeed be very appropriate,” said Lambright.

After surgery, Lyles contracted pneumonia in both lungs, which slowed his recovery.

The experimental procedure, not covered by medical insurance, cost between $300,000 to $600,000, Lyles said.  The family asked for at least $300,000 donation through the non-profit organization Help Hope Live, which works to fund uninsured transplant-related expenses.

“I hope my situation can help other people and we can lobby for those that don’t have a voice,” Lyles said.

Macchiarini and his surgical team have been performing the transplants since 2008, when they  transplanted a trachea using adult stem cells on a woman who suffered from tuberculosis. The procedure was first implemented on patients with tracheal cancer  in August 2010.

According to Macchiarini, the team collected stem cells from the two patients’ nose and bone marrow, and grew two different types of tissues from the cells that resembled the different surfaces of the trachea. The tissues covered the outer and inner linings of the donor trachea.

The team transplanted a new windpipe with tissue grown from her own stem cells and did not need to administer anti-rejection drugs, according to the case report, published in the December 2008 Lancet.

While the procedure seemed to have worked in a few patients, many experts said the method is still in the earliest stages of development.

“This is a research project and not a proven therapy,” said Dr. Larry Goldstein, director of the stem cell program at University of California San Diego. “There’s an important step from innovative therapy to the research needed to bring the innovative therapy to a large number of people.”

In fact, Goldstein said there’s a lot more information needed to know exactly how the procedure worked.

Lambright said it is still early to tell if the procedure works for a larger number of patients.

“We are a long ways away from knowing whether or not any of this has real durable application,” said Lambright.

But Lyles said that without the procedure his doctors told him he may not have been alive today.

“I think this is a viable solution to this type of cancer,” said Lyles. “I’m happy to have been a part of it.”

Macchiarini said this procedure could pave the way for other challenging transplants including the heart valve, chest wall, lungs and the esophagus.

“We need to be very cautious and don’t make hope for patients with cancer, because this is experimental,” said Macchiarini. “But so far the patients have had incredible results for an untreatable cancer.”