Archive for August, 2014

Feeling Deflated? The Lowdown On Low Testosterone

Sunday, August 17th, 2014

Manopause!  [Aging, insecurity and the $2 billion testosterone industry]

By David Von Drehle – Time Magazine – August 2014 Edition

Signs of Low T

An interesting article was written in Time Magazine this month providing the pros and cons of testosterone therapy.  Here is just a snapshot of some of the points covered. To read the full article you will need to login, subscribe or buy Time Magazine.  See link below.

It happens without warning.  Pizza and beer that once burned away quickly begin to cling to the belly.  Aches and pains that used to vanish overnight linger a few days, then a few weeks, then forever.  The eyes start to blur.  The ears muffle. Legs lose their spring. Cells mutate and cancers activate.  Most distressing for many men, one’s manhood itself changes. Once as eager as a Labrador puppy to jump up and play, more and more it resembles an old dog that would rather nap than fetch.

To quote T.S. Eliot, “time the healer is also time the destroyer.”

In 1939, two scientists shared their work in isolating and identifying testosterone.  Move on seven decades later and yearly U.S. sales alone of testosterone equated to $2.4 billion in 2013.  Projections for 2018 are $3.8 billion.  When it comes to testosterone therapy there are many studies out there to back up both sides of the argument.   Some Doctors fear that testosterone could inflame undetected tumors or bring on heart attacks Testosterone is believed to accelerate the growth rate of known prostate cancers, and suppressing the hormone is a standard part of treating advance cases of prostate disease.  However, several small samples of cancer patients who have tried T drugs have not found an appreciable increase in risk. Again, no large-scale clinical trials have been conducted.  The risk of pulmonary embolism – in which blood clots lodge in the lungs may increase.  A team led by Jacques Baillargeon of the University of Texas Medical Branch at Galveston found no elevated risk of heart attack.  No matter what you think of testosterone therapy, some scientist somewhere has data to back up the pros and the cons.

In a randomized, double-blind test of 30 men, they gave T shots to some of the subjects and harmless sesame-oil injections to the others.  All the test subjects were experiencing depression, and erectile dysfunction. Many of them reported improvements in their mood and function after treatment. But the doctors found no statistically significant difference in the progress of the T takers over the placebo group. Whether real or fake, the injections had the same effect on the patients.

Which is not to say testosterone is all in the mind. High doses of male hormones produce physical and emotional changes. Just look at the lads at your local high school who sprout from wisps to hulks in a matter of months. At puberty, a rush of testosterone courses through an unsuspecting boy, signaling that the time has come to sprout his beard, swell his muscles, lower his voice and fire his loins. The body responds with a total transformation.

Though not as abrupt or complete as menopause in women, andropause may be a reason older men lose muscle mass and libido and become more prone to weight gain around their middles – all of which are heralded by the low T marketers as symptoms of having low T.  Is low T actually the cause of andropause symptoms? Or is it a symptom itself, caused by other factors?  Advertisers assure men that dwindling testosterone levels invite belly flab.  But some experts argue the reverse is true, that the flab comes first and it is the cause of lower hormone levels and more exercise and a healthier diet will bring the levels up naturally.

Have you considered other reasons you may be experiencing fatigue, low sex drive and other symptoms?”  Harvard Men’s Health Watch recently asked:  “Do you eat a balanced, nutritious diet? Do you exercise regularly? Do you sleep well? Address these factors before turning to hormone therapy.”

“Testosterone is not a silver bullet,” says Mike Sisk, owner of the Low T Center chain, in the North Texas suburb of Southlake.  Sisk reports: “Testosterone makes a guy feel better. He starts working out a little more, drops a couple of pounds. But if you’re going to sit home and drink beer and eat pretzels, this is not gonna help you.”

Testosterone therapy can certainly represent new hope and a fresh start.  For the first time in years, the consumer feels happier and more energetic.  This can also be said for many health supplements out in the market.  Believing that he will feel better, he does.  Taking testosterone or a new health supplement can reverse the dismal cycle and soon all sorts of systems, from head to heart to groin, begin operating at a higher level.

Furthermore, the changes that men experience as they age are not simply expressions of hormone levels.  Genes and stem cells play a potent role, as do psychology and the environment. Likewise, weight gain happens for all sorts of reasons, and each one demands a different solution.

Sisk puts it this way:  “Our dads’ generation went quietly into the night.”  He continues, “My generation is not going quietly.”

To read this Time Magazine article in full click the following link:
http://time.com/magazine/us/3062871/august-18th-2014-vol-184-no-6-u-s/

The Ultimate Gift – Life Saving Stem Cells

Friday, August 15th, 2014

Graham Lewis and Sister Wendy Hamood

Reported by Medical Reporter, Brad Crouch of The Advertiser.

Mrs Hamood, 49, is about to give big brother Graham Lewis, 51, her stem cells in a risky and uncertain move to save him from a rare blood cancer.

Mr Lewis, a former PE teacher now in human resources, helped bring Kanga Cricket to South Australia in his first job with Cricket Australia.  The active father’s life changed abruptly when he was diagnosed with Mantle Cell Lymphoma in 2010, a disease that hits up to 350 Australians a year.

After chemotherapy, a stem cell transplant using his own cells in 2011 initially was successful. However, the disease returned this year and his hopes now hinge on a stem cell transplant from a donor – and here is where blood is thicker than water.

Only 25 per cent of siblings are matches. Both Mrs Hamood and brother Ivan, 43, volunteered immediately; Ivan was not suitable but Mrs Hamood was a match.

Mrs Hamood, a veterinarian with two children, knows the importance of family.

“I didn’t hesitate when this happened – I didn’t ever expect to confront something like this, but you play the hand you are dealt and have faith things will work out,’’ she said.

“We were close growing up and knowing Graham’s life is in my hands is a bit scary, but I am making sure I am as healthy as I can be. It is a big responsibility and Graham is depending on me, so I will do the best I can.”

Mr Lewis goes into Royal Adelaide Hospital on Monday for 10 days in isolation, where intense chemotherapy will aim to destroy the cancer but also break down his immune system, leaving him vulnerable to the slightest infection.

He has been checked for potential infection sources including any tiny specks of tooth decay behind fillings.

Mrs Hamood also will enter hospital for a week of hormone injections to encourage her bone marrow to over-produce stem cells.

Her blood will be extracted and put through a separator to harvest the stem cells, which will be injected into Mr Lewis’s blood in the hope he will develop a new immune system free of the lymphoma.

Mr Lewis is well aware of the risks as well as the rewards.

“This is a high-risk procedure only given to those who meet strict criteria, and some people do not survive,” he said.

“The main risks are from infections once the body’s immune system has been wiped out and before the new immune system has developed. Also from graft versus host disease, where the new immune system attacks healthy cells.

“My brother also would do the same if he were a match and I’d do the same for Wendy and Ivan, without hesitation.”

Mr Lewis will still be in hospital on September 17, his 20th wedding anniversary, but his wife and teenage son will be at Elder Park for the Leukaemia Foundation’s national Light the Night fundraiser for research. For more information, visit www.lightthenight.org.au .

STEM CELLS – GRAHAM’S JOURNEY SUMMARIZED

BETWEEN 175 and 350 Australians are diagnosed with Mantle Cell Lymphoma each year, a rare form of non-Hodgkin Lymphoma. Most are men aged over 60 and the cause is not known.

TREATMENT usually involves chemotherapy and radiotherapy. It can then involve a stem cell transplant using stem cells harvested from the patient.

IF this does not work, or if the patient relapses, a donor stem cell transplant may be an option.

ONLY about 25 per cent of siblings are suitable matches, and there are about 22 million adults willing to donate on global registries worldwide.

THE Royal Adelaide Hospital does about 40 stem cell transplants a year, most are for other types of blood cancers, with donors who may be strangers rather than siblings, and not all survive.

IN Graham’s case he will be in strict isolation for 10 days undergoing intensive chemotherapy to kill the cancer while destroying his own immune system, putting him at risk of the slightest infection.

HIS sister Wendy will spend a week injecting herself with a daily dose of Pegfilgrastim, a human granulocyte colony-stimulating factor, which will cause her bone marrow to overproduce stem cells which will flood into her blood stream ready for harvest on the day of the transplant.

BLOOD will be taken from Wendy’s arm, the stem cells separated, then the blood returned. There are few if any side effects for the donor.

THE transplant, where the stem cells are infused into Graham’s bloodstream, is scheduled for August 20, and Graham will spend at least six weeks in hospital hoping the stem cells kick start a new cancer-free immune system, that he remains clear of infections as it does, and that the transplanted stem cells do not attack his organs.